Signs of Narcolepsy: Overview

Narcolepsy is a strange neurological disorder with conditions of excessive sleepiness during the daytime; it is a condition that also causes muscle weakness. This disorder generally begins at the age of 15 to 25 years and can cause Cataplexy (muscle weakness), Hallucinations (vivid dreams occurring while asleep) and sleep paralysis (where the sufferer cannot move or speak, and which might last for few minutes after the sleep attack).

Narcolepsy Diagnosis

Narcolepsy is a rare and a complex neurological disorder that is commonly misdiagnosed. A doctor will assess the symptoms of this problem very easily by conducting certain laboratory tests as well as going through the patients’ history. A person who has this disorder can fall asleep frequently irrespective of the time and place.

Generally, an overnight polysomnogram is used for monitoring the person during the sleep and it also records the necessary details about the patient’s brain waves, eye movements, body position, heart rate, breathing or the muscle activity. A genetic blood test would also be taken if needed.

The multiple sleep latency test is usually taken from the patient in the day times. The other tests include Hypocretin test which tests the Hypocretin fluid present in the spinal cord using a lumbar puncture. When there are low levels of this fluid, people get Narcolepsy which promotes wakefulness.

It can be difficult to diagnose this condition if the signs and symptoms of Narcolepsy are very mild. At times, it might take even ten to fifteen years to diagnose since the symptoms get pronounced gradually. Thus, based on the patient’s family and medical history, laboratory test results, and by physical examination, the doctors could diagnose Narcolepsy in an individual.

Narcolepsy Risk Factors

The actual root cause of Narcolepsy is not known, however scientists have identified that it occurs by a genetic mutation, which results in abnormal sleeping patterns. The genetic cells control the brain chemicals that are responsible for sleeping cycles. Certain scientists proved that Narcolepsy occurs due to the presence of low levels of the Hypocretin (fluid that surrounds the spinal cord).

The Hypocretin fluid plays a major role in regulating the wakefulness and the sleeping patterns in an individual. Thus, there are numerous factors like hereditary, infections, brain injuries, auto immune disorders or low levels of histamine that contribute to interact between REM sleeping disturbances and the neurological dysfunction.

Many genetic factors largely contribute to the causes of Narcolepsy and around eight to ten percent of people having this disorder tend to have other victims in the family. However, it is not be the only factor but is usually combined with other immune problems. Sometimes even the environmental toxic substances like pesticides, weed killers and other chemicals contribute to the causes of Narcolepsy.

This neurological disorder affects both men and women, and usually the symptom starts to appear from the teenage but it’s quite rare to be found in children under five years of age. This disorder is considered to be a lifelong condition, but some narcoleptics can change their lifestyle with proper guidance and thus greatly improve the way that the condition presents in their day to day lives.

Narcolepsy Symptoms

Usually, the Narcolepsy disorder may be diagnosed at a very later stage with the symptoms such as cataplexy, hallucinations, sleep paralysis, micro sleep, and night time wakefulness, rapid entry into REM sleep and many other signs and symptoms.

The most common symptoms among them are cataplexy (muscle weakness) and extreme day time sleepiness. The patients affected with Narcolepsy tend to get these signs and symptoms when they experience deep emotional state of happiness, frustration, sadness or excitement. The symptoms may vary from person to person.

Cataplexy is a muscle weakness where there is a sudden loss of muscle tone in their body which is normally triggered by strong emotions. Hallucinations are vivid dreams that may be very sensual or frightening which occurs when they are awaken or at sleep.

Sleep Paralysis is a condition where the person is unable to move the body or unable to speak at the stage of awakening. The Micro sleep is a very short sleep that occurs less than five minutes when the person is involved in an activity.

Nighttime wakefulness is a condition where people are continuously awake the whole night, complete with fast heart rates and intense alertness. The Rapid entry into REM sleep is a condition where the person immediately reaches this stage once he falls asleep but usually it might take about ninety minutes for most of the people.

These symptoms might be either mild or even severe depending on the individual. There would be an automatic behavior of the persons affected with this disorder like falling asleep while eating or in the midst of any other activity.

Narcolepsy – Stages of the Disease

Usually, each patient affected by the Narcolepsy disorder has different symptoms that vary from person to person. The various stages involved in this disorder occur in various aspects of life. Most commonly, the physical well being of a person gets affected as he might unexpectedly fall asleep in the midst of activities like working, walking, driving, and cooking, which could be quite dangerous.

The mental health of a person is affected, which leads to depression, anxiety or stress. This can affect the social and professional relationships as well. One may think that the people affected by Narcolepsy are lazy by nature but this is not so. Due to extreme tiredness and sleepiness, impotency and low sex drive is often experienced by the victims of Narcolepsy. Even the memory and the attentive power is affected which results in forgetting things frequently.

Conclusion

There is no cure for the Narcolepsy disorder but the people affected by it can bring in some significant changes to their lifestyle and lead a better life. With proper medical help and guidance, patients can improve their alertness and can enjoy an active life by reducing their symptoms.

Cataplexy and Narcolepsy Basics

There are several narcolepsy symptoms and cataplexy is among the most common.   About seventy precent of people who suffer from narcolepsy also report cataplexy as one of their symptoms.   Cataplexy is a condition that although rare, is serious and disabling.  There is no none cure for narcolepsy or cataplexy. But there are treatments that can lessen the frequency and severity of the episodes.

The most common symptom of narcolepsy is cataplexy. When narcolepsy and cataplexy are together, it has its own biological markers that set it apart from narcolepsy without cataplexy. In “Narcolepsy, A clinical Guide” by Meeta Goswami, the predisposition to narcolepsy is looked at in a cross disciplinary fashion with both genetic studies and environmental factors getting equal scrutiny.  Goswami explains that as many advances have been made in recent years in the understanding of narcolepsy and that “in international classifications, narcolepsy with and without cataplexy are now two different diagnostic entries.”

Narcolepsy Diagnosis

Narcolepsy is a chronic sleep disorder; People who have a chronic sleep disorder like narcolepsy have problems sleeping. This nervous system disorder is characterized by the inability to control sleep cycles, extreme daytime sleepiness and a tendency to fall asleep at inappropriate times, like while driving or walking.  Although there are times when an attack is more likely, like after meals, times of impaired health or during high stress situations, a narcoleptic episode can happen at any time.  The disorder itself is not fatal, however, falling asleep while operating Machinery can be. For this reason, Narcolepsy sufferers often seek to control their disorder with drugs and behavior modifications, like scheduled short daytime naps and night sleep insomnia medication.

Cataplexy as narcolepsy Symptom

Experts recognize cataplexy as sign of narcolepsy.  Cataplexy is when a person has a sudden loss of muscle control and becomes weak. Cataplexy attacks are usually triggered by the act of laughter and extreme emotions.  Vigorous laughter is perhaps the most common trigger for a cataplectic attack.  There are several degrees a person can experience cataplexy.  A mild version of the symptom is when just the face goes slack or the eyelids droop.  This can happen for as little as a few seconds.  In extreme cases, control over the entire body is lost and can last for several minutes.  Unlike with plain narcolepsy, Cataplexy is experienced while completely awake, and alert.  So although they may be completely limp, they are aware of everything that is going on around them. This is what makes cataplexy frightening, especially the first time it is experienced.  A similar symptom is experienced in nighttime hours as sleep paralysis.

Protein Deficiency

No one knows what causes narcolepsy, but recent data indicates that the reduction of the Protein, Hypocretin-1 in the hypothalamus may be the cause of cataplexy in narcoleptic patients. A study was conducted in a sleep center in Brazil by Dr. F Coelho, by testing the spinal fluids of narcolepsy patients. It confirms that a reduction Hypocretin-1 is at least a positive biomarker for cataplexy. Patients without Cataplexy did not show reduced Hypocretin-1 levels. This makes it an effective biomarker for Cataplexy but not for Narcolepsy.

Autoimmune Disease Implications

It is well known that trauma can bring on both Narcolepsy and Narcolepsy with Cataplexy. Goswami states that in the genetics studies, there is a suggestion of possible autoimmune basis for the disease when cataplexy is present and hypocretin is deficient, because of the hypocretin cell destruction.  If this proves to be true, then scientists will have a new direction to look and new treatment options to explore.  Other Autoimmune diseases include Multiple Sclerosis and Rheumatoid Arthritis.

Cataplexy and Narcolepsy Symptoms in Children

Cataplexy and narcolepsy signs that develop in school age children are very uncommon and are usually misdiagnosed due to cataplexy diagnosis currently being based at 100% specific on medical history. The impact narcolepsy can have on a child’s life can be devastating. E.D.S. or excessive daytime sleepiness can cause sleep attacks at unusual periods throughout the day and is commonly linked to cataplexy. The child experiencing this will lose control of his or her muscle functions while being awake. This is usually triggered by laughter and the end result is a fall, which can cause physical harm.

There are several narcolepsy signs and cataplexy is only one. Sleepwalking, for instance is a common symptom. Sleep paralysis is another symptom that is often reported. This can be a horribly frightening experience for children, as they are totally aware of their surroundings, but are unable to move or speak. Other symptoms that have been noted are depression of various ranges, obesity and sleep disturbances in which the child may not be able to distinguish reality from dreams.

Treatment for narcolepsy in children is a highly demanding effort, which includes medication as well as non-medical treatment. Correct diagnosis is paramount for children to gain benefits from treatment. The medicines include sodium oxybate, stimulants and antidepressants. The extra treatments include scheduled napping, environmental adjustments and understanding. This strategy can help children who suffer from narcolepsy to attain a meaningful life.

Narcolepsy/Cataplexy Studies

Narcolepsy has been extensively studied, but the exact cause remains a mystery. It has been suggested that excessive daytime sleepiness is a genetic factor, but narcolepsy is rarely found in relatives. Narcolepsy studies point to disorders of the cerebral pathways that control a person’s ability to stay awake or asleep.

Cataplexy, although defined, is not very precise by that definition; meaning that the distinction between typical and atypical cataplexy is not well recorded. Recent studies have been aimed at finding a more distinct definition for cataplexy as well as grading it by levels of severity. The patients included in the study were those with recorded cataplexy histories and hypocretin-1 deficiencies. A questionnaire containing items that covered a wide range of cataplexy symptoms, including triggers, duration, associated aspects and limitation in a person’s daily life, was given to these patients.

The results placed 60% of the patients with spontaneous cataplectic attacks, with 45% of these patients having both partial and complete cataplectic attacks. Of the patients as a whole, only 15% had symptoms lasting more than 2 minutes. Of triggers, laughing ranked lower than anger as a whole, with laughing hysterically triggering more attacks, which showed that intensity of certain emotional states has a direct impact on cataplexy. Of all the muscles affected during cataplectic attacks the jaw and facial muscles showed a higher rate of involvement in partial attacks.

Famous People with Narcolepsy: Do you Know Who They are?

Harriet Tubman

When it comes to the fight for American civil rights, Harriet Tubman is much more than a woman; she is an institution, and she had Narcolepsy. Born in either 1819 or 1820 into a life of slavery, Tubman was an African-American abolitionist all her life at a harsh plantation in Maryland. Subject to cruel ownership, bitter working conditions, and painful punishments, this brave woman spent her entire life, as a slave, fighting for the equality of African-Americans and the abolishment of slavery.

At the age of twelve, Harriet received a brain injury that would affect her for the rest of her life. An attempt to help a fellow escape had gone awry, and the runaway slave was captured. Harriet refused to follow her overseer’s directions and tie up the escaping slave. Angry at her disobedience, the overseer delivered a harsh blow to the front of her head. The blow was so intense that she suffered a permanent indention in her forehead. The trauma Harriet received caused her to suffer from Narcolepsy and seizures; she later developed chronic headaches and suffered life-long as a result of the beating.

Harold Ickes

An accomplishment not many can claim, Harold Ickes is one of few politicians who is known for falling asleep on the job- in the White House! Campaign advisor to Davis Dinkins during his run for New York Mayor, Ickes was a respected and honored White House Deputy Chief of Staff during the presidential reign of Bill Clinton; Ickes also headed Clinton’s campaign during the presidential race in 2002. During Bill’s famous scandal, Ickes worked hard to help save the reputation of the Clinton family.

It is rumored that Harold Ickes, while a passionate politician and respectable man, suffered from the plagues of Narcolepsy. He would fall asleep at inappropriate times, very often while on the job. He was actually prescribed amphetamine medication to help him stay awake during the day like many Narcolepsy patients today. Ickes didn’t take the medication often because it would cause him to suffer from a new plague, Insomnia. Some people claim that many years of Narcolepsy, daytime sleepiness, and sudden naps, Harold Ickes had become much more defensive, and even displayed a few moments of public vulgarity.

Natassja Kinski

When you hear the name, Natassja Kinski, you don’t think of the word disorder; it should be the farthest thing from your mind. A disorder, however, is exactly what this German actress has. Natassja Kinski is one of the most famous narcoleptic sex symbols in the world. During the 1970s and 1980s, this gorgeous actress was a household name in Germany after starting her career as a model. Later, she turned her interests towards to the Silver Screen. Kinski even won a Golden Globe for her brilliant performance in “Tess”. Despite suffering from an unpredictable disorder like Narcolepsy, Kinski was able to appear in over sixty movies in her entertainment career.  During an interview, Kinski even revealed that she avoids driving at night because she takes her Narcolepsy and the dangers associated with it seriously.

Jimmy Kimmel

James Christian “Jimmy” Kimmel is one of pop culture’s most popular famous people with Narcolepsy. Kimmel is one of comedy’s most celebrated comedians, and is most famous for hosting his late-night talk show, Jimmy Kimmel Live! on ABC. In addition to hosting his talk show Kimmel also co-hosted The Man Show, and Win Ben Stein’s Money on Comedy Central. An accomplished producer, Kimmel has also produces famous shows like The Andy Milonakis Show, The Sports Show with Norm McDonald, and Crank Yankers.

Jimmy Kimmel is one of the most famous people in the media spotlight today who uses his platform to talk publicly about Narcolepsy. He has not been ashamed to share his personal struggle with the disorder with a public who may gain some help or comfort in his story. The comedian was diagnosed with the sleep disorder until his thirties. In an interview with Esquire, the hilarious host got up close and personal about the pains and pressures of Narcolepsy. He said, “You know how when you’re regular tired, your whole body is tired? With narcolepsy, just the inside of your head is tired. It’s like somebody’s gently sitting on your brain. You have almost no focus. All you’re thinking about is not falling asleep.”

Teresa Nielson Hayden

Born on March 21, 1956, Teresa Nielson Hayden would grow up to become on the most famous people with Narcolepsy to ever write literature. Hayden was raised in Arizona where she later became and managing and consulting editor to a company called Tor Books. The American essayist is famous for her work as a science fiction editor and fanzine writer. Teresa Nielson Hayden also manages her own weblog; the blog has become quite popular, and her entries cover a wide variety of topical and interesting material. Throughout her career, Hayden was nominated for five separate Hugo awards.

Hayden was open about her struggles with Narcolepsy and the disorder’s difficult side effects. Not many Narcolepsy patients are able to function adequately in the literary world, a world that requires stillness and focus, but Hayden proves that anything is possible. Hayden’s public acceptance of her sleep disorder, and her admittance of medicated treatment, inspired people all over the country to seek diagnosis and treatment.

Famous Fictional People with Narcolepsy Disorder

Tyler Durdern: The infamous main character of the novel Fight Club, Tyler Durden is a schizophrenic narcoleptic whose self-destructive hallucinations get him into a big heap of trouble. Edward Norton played his character in the movie co-starring Brad Pitt.

Argentinean: With a modernized stylistic revision of classic musical numbers, an artistic directing style, and an all-star cast, Moulin Rogue has easily become one of the most popular musicals of the last thirty years. In the film, there is an outlandish, eccentric Bohemian artist with Narcolepsy known only as, “the Argentinean Narcoleptic”. The hero’s involvement in the plot of the play becomes solidified when the unreliable narcoleptic foreigner cannot stay awake long enough to complete the show.

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